Anti-Müllerian hormone levels among contraceptive users: evidence from a cross-sectional cohort of 27,125 individuals

BackgroundAnti-Müllerian hormone has become the clinical biomarker-based standard to assess ovarian reserve. As anti-Müllerian testing becomes more common, individuals are seeking interpret values obtained while using contraceptives. To appropriately counsel women, a better understanding of levels in women different contraceptives is needed.ObjectiveTo study association between forms and reproductive age.Study DesignThis cross-sectional including 27,125 US-based aged 20 46 years, accessing results through Modern Fertility who provided informed consent participate research. Anti-Müllerian were collected dried blood spot card (95.9%) or venipuncture (4.1%), previous work shown high correlation by these 2 methods. Multiple linear regressions run compare with not on any contraceptive, controlling for age, age menarche, body mass index, smoking, sample collection method, cycle day, self-reported polycystic ovary syndrome diagnosis. We also analyzed whether duration contraceptive use predicted users hormonal intrauterine device combined oral pill, given size groups.ResultsMean statistically significantly lower pill (23.68% lower; coefficient, 0.76; 95% confidence interval, 0.72–0.81; P<.001), vaginal ring (22.07% 0.78; 0.71–0.86; (6.73% 0.93; 0.88–0.99; P=.014), implant (23.44% 0.77; 0.69–0.85; progestin-only (14.80% 0.85; 0.76–0.96; P=.007) than when covariates. comparing those copper (1.57% 0.98; 0.92–1.05, P=.600). Associations did differ based Duration use, but was slightly positively associated levels, although this small magnitude effect likely clinically meaningful (coefficient, 1.002; 1.0005–1.003; P=.007).ConclusionCurrent mean level that contraceptives, variability percent difference across These data provide guidance clinicians how assessed may facilitate patients continue being evaluated their needed. age. This groups. Mean P=.007). Current